Marius Lamberty
Neuronal correlates of time integration into memories
The Brain Dynamics Graduate School invites you to the talk:
Dr Marius Lamberty
Department of Animal Physiology, Institute of Biology, Faculty of Life Sciences, University Leipzig
“Neuronal correlates of time integration into memories”
24th September 2024, 11:00
BBZ Seminar room
Deutscher Platz 5, 04103 Leipzig
Abstract:
Memory performance is regulated by the circadian clock throughout the animal kingdom – including Drosophila melanogaster. The major clock neurotransmitter Pigment-dispersing factor (PDF) has been shown to attenuate memory performance in a time of day-dependent manner, however a direct, functional connection between PDF-releasing cells and the mushroom bodies has not yet been demonstrated. This study suggests that Diuretic hormone 31 (DH31)-positive clock neurons of the DN1p cluster tune memory performance downstream of PDF-releasing s-LNv neurons. DH31, a functional homolog of the mammalian calcitonin gene-related peptide, acts in a pleiotropic fashion. While DH31 mainly facilitates memory performance, DH31 specifically limits memory performance in the evening by acting directly on the mushroom bodies. DH31 therefore acts as a clock communication signal that confines memory performance to a physiological dynamic range.